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PARKINSON'S DISEASE

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          ⭐ PARKINSON'S DISEASE ⭐ 1) DEFINITION of Parkinson's disease -      Parkinson's disease is a chronic and progressive disease of nervous system which is characterized by features like tremor , rigidity , akinesia (or bradykinesia) and postural instability . ( The pneumonic for these features is TRAP i.e tremor, rigidity, akinesia, postural instability )     2) ETIOLOGY of Parkinson's disease -      (a) Primary causes - These include                   Idiopathic parkinsonism                   Parkinson's disease                   Paralysis agitans            ( Primary causes have origin of their own ... There is absence of any underlying  factor or cause )        (b) Secondary causes - Here, there are some underlying factors present .              (I) Infections - HIV , influenza                  (Infections lead to inflammation                  which causes release of                  different cytokines and                   mediators. Signalli